Despite being one of the main European Union (EU) policy goals, expressed in the EU treaty and expected to be fostered by EU Cohesion Policy, territorial cohesion is still an under-researched scientific concept and policy process. Against this background, this special issue provides novel theoretical and practical perspectives on the relationship between EU Cohesion Policy and territorial cohesion, particularly through the analysis of EU Cohesion Policy impacts and its contribution to territorial cooperation processes, regional and urban development strategies, as well as sustainable transitions.